Mithilesh Chaturvedi is a popular supporting artist in Hindi movies. One of his earliest known works is the Taal, which had Anil Kapoor, Aishwarya Rai Bachchan, and Akshaye Khanna in the lead roles. The movie was directed by Subhash Ghai. He did that film in 1999 and played the role of Rambhajan. He did a small role in the 2001 Amitabh Bachchan starrer Aks. He has also done a supporting role in Road in 2002 and Bunty and Babli in 2005. In 2006, he played a minor role in Rakesh Roshan’s science fiction superhero flick, Krrish.

Mithilesh played the character of Zakaria in the 2007 Feroz Abbas Khan’s movie, Gandhi, My Father, which was based on the troubled relationship between Gandhi and his eldest son. In 2007, he was also seen in the movie Salaam Bacche. He played the role of a defense lawyer in the 2011 movie, Monica, which shows the story of an ambitious woman who wants to rise to the top at any cost. In 2009, he played the role of Katrina Kaif’s (Jenny) father, Mr. Pinto, in the movie Ajab Prem Ki Ghazab Kahaani. In 2013, he appeared in a movie Sooper Se Ooper, but the movie didn’t turn out well. In 2013, he appeared in another picture, Phata Poster Nikla Hero, which had Shahid Kapoor and Ileana D’Cruz in the lead roles. The film was directed by Rajkumar Santoshi.
 

In 2015, Mithilesh appeared in Mohalla Assi alongside Sunny Deol, which is a movie about the Mandal Commission implementation. Currently, he is seen playing the role of Aatmaram Chaubey in the Hindi Tv serial Neeli Chatri Waale, aired on Zee TV. The show is about a common man who is torn between his personal and professional life.